Exogenous Melatonin Ameliorates Pontine Histoarchitecture and Associated Oxidative Damage in Sodium Fluoride Induced Toxicity
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چکیده
منابع مشابه
Melatonin ameliorates oxidative damage in hyperglycemia-induced liver injury.
PURPOSE Melatonin (N-acetyl-5-methoxy-tryptamine) is synthesized mainly by the pineal gland and its antioxidant properties have been demonstrated both in short and long term studies. Our aim was to clarify the effects of hyperglycemia and to administer melatonin on lipid peroxidation, protein oxidation and oxidative DNA damage in rat. METHODS Malondialdehyde (MDA), protein carbonyl (PCO) and ...
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The oxidative damage and morphological changes of kidneys of rats exposed to cadmium (5 mg Cd /kg b.w) for 22 days and the protection using melatonin (10 mg/kg b.w) against cadmium toxicity was studied. Malondialdehyde (MDA) concentration as a lipid peroxidation indicator, activity of the antioxidant enzyme superoxide dismutase (SOD) and the concentration of glutathione (GSH) were measured in k...
متن کاملEffect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues.
This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level ...
متن کاملCopper ameliorates fluoride toxicity in fluoride and molybdenum fed rabbits.
Hydrofluorosis is a major public health problem in India, which is aggravated by presence or absence of some minerals in water or food. Fluoride by itself or in combination with other elements like molybdenum (Mo) in diet or water changes excretion/retention of bone minerals. Sorghum and pearl millet grown and consumed in fluorosis endemic areas contained significantly higher amounts of Mo than...
متن کاملCurcumin Ameliorates Sodium Valproate Induced Neurotoxicity through Suppressing Oxidative Stress and Preventing Mitochondrial Impairments
Background and purpose: Curcumin is a natural polyphenolic compound in turmeric (Curcuma longa). Curcumin has potent free radical scavenger and antioxidant properties that could significantly reduce oxidative damage. Oxidative stress and mitochondrial dysfunction contribute to valproate sodium induced tissue damage. This study investigated the protective effects of curcumin against valproate so...
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ژورنال
عنوان ژورنال: Nepal Journal of Neuroscience
سال: 2020
ISSN: 1813-1956,1813-1948
DOI: 10.3126/njn.v17i2.30110